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Jody Jonathan Haigh, Ph.D.

Biography

Full CV

The Haigh Lab

Cutting Edge Technologies in Leukemia Research

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The Haigh Lab located at the Paul Albrechtsen Research Institute at CancerCare Manitoba and the University of Manitoba uses cutting edge technologies to understand molecular mechanisms responsible for controlling blood cell development and how blood cancers arise.

We are continuing to study the role the ZEB and SNAI family of transcription factors and their roles in normal blood cell development and how when these factors become deregulated  can drive aggressive forms of blood cancer.

Our Research Interests

Montage of experiments

At the Haigh Lab, we are dedicated to conducting research on molecular mechanisms responsible for controlling blood cell development and how blood cancers arise. We strive to use the latest technologies to further our understanding of this important area of study. Our team is passionate about making a difference in the lives of those affected by blood cancers and we are committed to advancing this field of science.

  • In vivo  Disease Modelling and Imaging

  • ​Epigenetic and Transcription Factor Crosstalk

  • Single cell and global RNAseq analysis

  • Proteomic approaches such as TurboID

  • Drug Synergy screens

  • Primary patient sample screens

The Haigh Lab

Dedication. Expertise. Passion.

We are an international team of investigators trying to make a difference in the lives of cancer patients.  Particularly those afflicted with aggressive forms of blood cancer.

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Publications

STAT5 activation promotes stemness and therapeutic resistance of leukemia-regenerating cells.

Cedric S. Tremblay, Jesslyn Saw, Jacqueline A. Boyle, Katharina Haigh, Veronique Litalien, Hannah McCalmont, Kathryn Evans, Jessica M. Salmon, Richard B. Lock, Stephen M. Jane, Jody J. Haigh, and David J. Curtis

Blood Journal, March 29, 2023 [IF=25.48]

Full Publication List

JAK/BCL2 inhibition acts synergistically with LSD1 inhibitors to selectively target ETP-ALL.

Aissa Benyoucef, Katharina Haigh, Andrew Cuddihy, Jody J. Haigh

Leukemia 2022, Oct 13. 36:2802-2816 [IF=11.53]

Interplay between the EMT transcription factor Zeb1 and Zeb2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity.

Jueqiong Wang, Carlos Farkas, Aissa Benyoucef, Catherine Carmichael, Katharina Haigh, Nick Wong, Danny Huylebroeck, Marc P. Stemmler, Simone Brabletz, Thomas Brabletz, Christian Nefzger, Steven Goossens, Geert Berx, Jose M. Polo, Jody J. Haigh

PLOS Biology 2021 19(9): e3001394 [IF=9.59]

Contact

Funding Organizations

We are extremely grateful to the funding agencies and charities that have funded our research.
CIHR Logo

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CancerCare Manitoba Foundation Logo
Research Manitoba Logo
Canada Foundation for Innovation Logo
Rare Disease Models and Mechanisms Network Logo

Contact

675 McDermot Ave, ON5029 Winnipeg, MB Canada, R3E 0V9

204-588-8450

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Help Solve the Puzzle

For over two decades, the Haigh Lab has been at the forefront of blood cancer research, identifying novel targets and drug combinations to help those battling this disease. We are proud of our team’s accomplishments, and we continue to explore new opportunities to further our mission. Our ongoing research projects are aimed at identifying the underlying genetic and molecular mechanisms of blood cancer and developing personalized treatments that can target blood cancer cells more effectively. Join us in our fight against cancer today.

Present Job Opportunities

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